Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

The ActiLiège-Adult study is a prospective, longitudinal, observational study designed to collect natural history data on adult patients with neurological or metabolic diseases affecting movement. Conducted at the Centre de Référence Liégeois des Maladies Neuromusculaires in Liège, Belgium, the study will enroll 300 ambulant patients, including individuals with neuromuscular disorders and obesity. Using the Syde® wearable device, the study aims to continuously monitor motor function in real-life settings over a period of up to two years. The primary objective is to evaluate the utility of digital mobility outcomes, such as the 95th centile of stride velocity (SV95C), as reliable and objective endpoints for future clinical trials.

NCT Number	NCT07136844
Lead Sponsor	Centre Hospitalier Universitaire de Liege Collaborators: Centre Hospitalier Régional de la Citadelle, SYSNAV
Conditions	Neuromuscular Diseases, Obesity (Disorder), Myotonic Dystrophy 1, Myasthenic Syndrome, Charcot Marie Tooth Disease (CMT), Glycogen Storage Disease Type II Pompe Disease, Facio-Scapulo-Humeral Dystrophy, Myasthenia Gravis +4 more
Enrollment	300 participants
Start Date	2024-03-29
Primary Completion	2029-12 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2025-08-22