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Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban

Study acronym: INSIST-IT2
StatusRecruiting
PhasePhase 3
Started
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Record History

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  1. Trial status: Not Yet Recruiting to Recruitingv3 Show 8 more changesShow less
    • Primary completion date: Mar 31, 2027 to Sep 30, 2027
    • Primary endpoint revised
    • Enrollment target: 884 to 870
    • Study completion date: May 31, 2027 to Dec 30, 2027
    • Start date changed from estimate of Oct 1, 2025 to Nov 13, 2025
    • Eligibility criteria expanded, about 24 words
    • Secondary endpoints: 13 to 14
    • Site details revised
  2. Secondary endpoints: 14 to 13
    • Eligibility criteria shortened, about 1 word
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
It remains uncertain whether intravenous tirofiban administered before endovascular thrombectomy could improve disability severity for patients with LVO due to intracranial atherosclerosis.The current study aimed to assess the efficacy and safety of administering intravenous tirofiban before endovascular thrombectomy for improving clinical outcomes in patients with anterior circulation LVO due to intracranial atherosclerosis.
Trial Details
NCT Number NCT07135089
Lead Sponsor General Hospital of Shenyang Military Region
Conditions
(from sponsor)		 Stroke, Ischemic
Related terms Ischemic Stroke
Enrollment 870 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov