Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury

Knee osteoarthritis is a complex condition, and selecting effective non-drug treatments like orthoses or exercise is often difficult and imprecise. This study will follow individuals with early-stage knee osteoarthritis or previous anterior cruciate ligament injury to develop computational models that predict cartilage degeneration and pain over time. The models will integrate data from medical imaging, movement analysis, muscle strength testing, pain assessments, questionnaires, and biomarkers to improve personalized treatment planning.

NCT Number	NCT07134244
Lead Sponsor	Aalborg University Collaborators: Lund University, University of Eastern Finland, Aalborg University Hospital
Conditions	Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries
Enrollment	105 participants
Start Date	2024-09-26
Primary Completion	2035-09-26 (estimated)
Study Completion	2036-09-26 (estimated)
Updated on ClinicalTrials.gov	2025-08-21