Clinical Trial

AI-Guided Treatment Planning in Orthodontic Patients With Missing Upper Lateral Incisors

Study acronym: SMILE-AI
Active, Not Recruiting
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Record status
This record was last updated August 21, 2025 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.
Summary
This pilot study aims to evaluate the diagnostic accuracy of artificial intelligence (AI) in orthodontic treatment planning for patients with congenitally missing upper lateral incisors. The study compares AI-generated treatment recommendations with decisions made by experienced orthodontists regarding two main treatment options: space closure and prosthetic replacement. Orthodontic records, including intraoral and extraoral photographs, panoramic radiographs, and cephalometric analyses, will be collected for each case. Two orthodontists with over 10 years of clinical experience will independently evaluate each case using a treatment decision checklist with predefined cutoff points. AI predictions will then be compared to orthodontists' consensus decisions to determine agreement rates and accuracy. The findings will provide insight into the potential role of AI in supporting complex orthodontic decision-making.
Trial Details
NCT Number NCT07133867
Lead Sponsor Cairo University
Conditions Orthodontic Treatment Planning, Congenitally Missing Maxillary Lateral Incisors
Enrollment 110 participants
Start Date 2024-03-28
Primary Completion 2026-03 (estimated)
Study Completion 2026-08 (estimated)
Updated on ClinicalTrials.gov 2025-08-21