Clinical Trial

Abuse Liability for Five Modern Oral Nicotine Products

Recruiting
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Record status
This record was last updated December 30, 2025 (before its estimated April 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a two-site, open-label, randomized, 4-way (2 arm) cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics \[PD\]) and plasma nicotine uptake (pharmacokinetics \[PK\]) during and following ad libitum use of the study investigational products (IPs) by generally healthy smokers
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-08-13.
Status change: Not Yet Recruiting → Recruiting 2025-12-22
Trial Details
NCT Number NCT07132814
Lead Sponsor RAI Services Company
Conditions Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Enrollment 40 participants
Start Date 2025-12-15
Primary Completion 2026-04-15 (estimated)
Study Completion 2026-08-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-30