Clinical Trial

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

Study acronym: SMARTER-CMR
Recruiting
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Summary
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER. The target sample will be up to 125 patients enrolled to achieve 100 evaluable at 6 months of follow-up. Enrollment will occur at up to eight centers.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-08-12.
Trial Details
NCT Number NCT07131631
Lead Sponsor Minneapolis Heart Institute Foundation
Conditions Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Enrollment 125 participants
Start Date 2022-03-03
Primary Completion 2027-07 (estimated)
Study Completion 2027-07 (estimated)
Updated on ClinicalTrials.gov 2025-12-23