Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes. We will be comparing the responses in individuals who are taking metformin to those who are naive to metformin. The results from this study may help identify non-pharmacological interventions in prediabetes.

NCT Number	NCT07131384
Lead Sponsor	University of Virginia
Conditions	Males, Females, Sedentary, Metformin, Prediabetes
Enrollment	24 participants
Start Date	2026-01-01
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-03