Clinical Trial

Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients Using Hybrid Digital Twin Solutions

Study acronym: SMASH-HCM
Active, Not Recruiting
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Summary
The goal of SMASH-HCM is to develop a digital twin or virtual model of the heart and vascular system with sympathetic nerve control that integrates multi-scale and multi-organ spatiotemporal biophysical data from a multitude of sources. SMASH-HCM's digital twin powered platform will dramatically improve hypertrophic cardiomyopathy (HCM) patient stratification and disease management through stepwise deep phenotyping integrated in clinical and patient-guided workflows.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-08-15.
Trial Details
NCT Number NCT07131371
Lead Sponsor Tampere University
Collaborators: University of Bologna, Universita Degli Studi di Firenze, Rennes University Hospital, University of Milan, University College Dublin, Universitätsklinikum Hamburg-Eppendorf, Medtronic Bakken Research, Pharmatics Limited, University of Oxford, University of Rennes 2
Conditions HCM - Hypertrophic Cardiomyopathy
Enrollment 2,500 participants
Start Date 2024-01-15
Primary Completion 2026-12-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-08-27