National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial

Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only \~2,500 performed, non-transplant options are urgently needed. Regenerative therapy, especially MSCs, shows promise but lacks validation, particularly for non-viral ACLF. The proposed NC-CHRM aims to develop and validate MSC-based therapy to promote native liver regeneration and offer a safe, effective, transplant-free treatment.

NCT Number	NCT07131306
Lead Sponsor	Institute of Liver and Biliary Sciences, India Collaborators: Indian Council of Medical Research
Conditions	Acute-On-Chronic Liver Failure
Enrollment	100 participants
Start Date	2027-01
Primary Completion	2031-08 (estimated)
Study Completion	2031-08 (estimated)
Updated on ClinicalTrials.gov	2025-08-20