European Registry Study on Lymphatic Interventions

This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders. The study will examine the effectiveness of diagnostic imaging and interventional techniques, such as lymphatic embolization, in improving clinical symptoms, biomarkers, and fluid-related complications. The central question is whether early diagnosis and targeted intervention can lead to clinically meaningful improvements and reduced need for reintervention. Data collected retrospectively and prospectively from participating centers will help identify predictors of outcome, assess disease severity, and inform standardized diagnostic and therapeutic pathways across Europe.

NCT Number	NCT07131293
Lead Sponsor	Rigshospitalet, Denmark Collaborators: UZ Leuven, Leuven, Belgium, UCL Bruxelles, Lund University Hospital, University Hospital Schleswig-Holstein, University Hospital, Aachen, Deutsches Herzzentrum Muenchen, Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, UZ Gent, Belgium, Hospital for Children and Adolescents, University of Helsinki, Hospital Universitari Vall d'hebron Barcelona, Spain, Children's University Hospital, Ireland, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Bambin Gesù Hospital IRCCS, Rome, Italy
Conditions	Lymphatic Disorders, Plastic Bronchitis, Protein Losing Enteropathy, Chylothorax, Lymphatic Abnormalities
Enrollment	500 participants
Start Date	2026-02-01
Primary Completion	2030-03 (estimated)
Study Completion	2030-03 (estimated)
Updated on ClinicalTrials.gov	2026-01-21