Relationship Between Malocclusion Severity and Periodontitis Risk

The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers. The main question it aims to answer is: Does increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL/OPG balance and oxidative stress levels? Participants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.

NCT Number	NCT07127744
Lead Sponsor	Recep Tayyip Erdogan University Training and Research Hospital
Conditions	Malocclusion
Enrollment	70 participants
Start Date	2025-09-15
Primary Completion	2025-12-15 (estimated)
Study Completion	2026-01-19 (estimated)
Updated on ClinicalTrials.gov	2025-08-22