The goal of this observational study is to learn about the natural history and multi-organ involvement of Laminin-Alpha-2-Related Dystrophy (LAMA2-RD) in pediatric and adult patients. The main questions it aims to answer are:
* What is the prevalence and nature of cardiac involvement, and how do this relate to age and muscular phenotype?
* What is the prevalence of peripheral neuropathy, and how do this relate to age and muscular phenotype?
* What is the extent of respiratory, nutritional, skeletal, and cognitive/brain involvement, particularly in adults with more severe vs less severe phenotypes?
* How does quality of life and transition to adulthood occur in individuals with LAMA2-RD?
* Which nomenclature best reflects differences in disease severity and may support future clinical trial design?
Study participants will:
* Undergo retrospective and prospective clinical assessments every 12 months for 2 years across multiple centers.
* A subset of adult participants (n=20) will receive cardiac MRI with contrast enhancement.
* Provide biological samples during routine blood testing for future research.