Sore Throat After Open Neck Elective Surgery

This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough following thyroid or parathyroid surgery with neuromonitoring. A total of 764 adult patients undergoing elective neck surgery at Saint-Petersburg State University Hospital will be enrolled and randomly assigned to receive either a hydrocortisone-coated or lidocaine-coated endotracheal tube. Outcomes will be assessed upon awakening from anesthesia, at 24 hours, and again at 3 days postoperatively. The findings may contribute to improving postoperative comfort and recovery for patients undergoing similar surgical procedures.

NCT Number	NCT07124650
Lead Sponsor	Saint Petersburg State University, Russia Collaborators: Smooth Drug Development
Conditions	Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery
Enrollment	764 participants
Start Date	2025-09-15
Primary Completion	2026-12 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-04-13