Clinical Trial

Alpha-Blockers Prior to Ureteral Access Sheath Placement in Flexible Ureteroscopy: A Randomized Prospective Study

Study acronym: ALFA-URS
Recruiting Phase 4
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Record status
This record was last updated August 15, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study aims to evaluate whether the use of alpha-blockers before flexible ureterorenolithotripsy facilitates the passage of the ureteral access sheath. The trial will enroll adult patients diagnosed with kidney stones who are scheduled for flexible ureteroscopy. Participants will be randomly assigned to receive or not receive alpha-blockers for seven days before surgery. The primary outcome is the rate of successful sheath placement without the need for a second procedure. Secondary outcomes include the incidence of ureteral injuries and the need for additional surgical interventions. The goal is to improve surgical efficiency and patient outcomes in the treatment of kidney stones.
Trial Details
NCT Number NCT07124299
Lead Sponsor Pedro de Figueiredo Buchalla
Conditions Nephrolithiasis, Alpha Blocker, Ureteral Access Sheath
Enrollment 140 participants
Start Date 2024-01-01
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-02-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-15