Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity

Patients with concurrent Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO) represent a clinically challenging subgroup, often experiencing refractory gastrointestinal symptoms and diminished treatment responses. Current evidence indicates that individuals infected with H. pylori may related SIBO as a comorbidity; however, the synergistic effects of these conditions on gut ecosystem homeostasis remain poorly understood. To address this knowledge gap, we employed a dual-omics approach that combined shotgun metagenomic sequencing with liquid chromatography-mass spectrometry (LC-MS) metabolomic profiling. This methodology allowed for a comprehensive mapping of microbial community structures, including species-level taxonomy and functional pathways, as well as host-microbiota co-metabolism signatures in fecal samples.

NCT Number	NCT07122284
Lead Sponsor	Zhongshan Hospital (Xiamen), Fudan University
Conditions	Gut Microbiota, Metabolic Profiles, Helicobacter Pylori Infection, Small Intestinal Bacterial Overgrowth
Enrollment	42 participants
Start Date	2024-01-31
Primary Completion	2024-12-30 (estimated)
Study Completion	2025-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-25