Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction

This experimental study explores the neurophysiological mechanisms associated with pain modulation following a single session of low-intensity resistance exercise combined with BFR in healthy young adults. The study evaluates changes in sensory thresholds before and after the intervention using validated quantitative sensory testing (QST) methods. These include pressure pain thresholds, conditioned pain modulation, thermal thresholds, and temporal summation. The findings may contribute to a better understanding of the role of the nervous system in exercise-induced hypoalgesia, particularly in response to BFR protocols, with implications for future research in pain and rehabilitation.

NCT Number	NCT07122011
Lead Sponsor	University of Gran Rosario
Conditions	Healthy
Enrollment	20 participants
Start Date	2025-08-04
Primary Completion	2026-02-19 (estimated)
Study Completion	2026-02-19 (estimated)
Updated on ClinicalTrials.gov	2026-05-04