Optimizing Metformin Use in Polycystic Ovary Syndrome

The goal of this clinical trial is to learn if a metformin dose of 1500 mg or 2250 mg per day is better to treat polycystic ovary syndrome (PCOS) in adults. It will also learn about the adverse effects of metformin. The trial aims to evaluate which metformin dose is better for: 1. improving biochemical and clinical outcomes 2. gastrointestinal side-effects 3. mental health and quality of life Participants will: * Be randomized to take metformin at a dose of either 1500mg or 2250mg every day for 6 months * Visit the clinic three times during the trial for checkups and tests * Answer questionnaires on menstrual cyclicity, mental health, quality of life and side-effects

NCT Number	NCT07120815
Lead Sponsor	Helsinki University Central Hospital Collaborators: Valtion tutkimusraha (funding), Sakari Alhopuro foundation (funding), The Medical Society of Finland (funding)
Conditions	Polycystic Ovary Syndrome (PCOS)
Enrollment	184 participants
Start Date	2025-09-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-08-13