Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study

This prospective, single-center, single-arm study evaluates the feasibility, safety, and rapid recovery outcomes of a tubeless strategy in lung transplantation. Consecutive eligible adult lung transplant recipients undergo lung transplantation without standard endotracheal intubation, using a laryngeal mask airway and standardized regional anesthesia and intravenous sedation protocols. The primary outcome is freedom from invasive ventilation in the operating room, defined as removal of the airway device before leaving the operating room with no reinstitution of invasive ventilation within 72 hours. Secondary outcomes include postoperative ICU length of stay, postoperative hospital length of stay, postoperative invasive ventilation requirement, postoperative complications (assessed up to 30 days), and perioperative mortality.

NCT Number	NCT07120230
Lead Sponsor	The First Affiliated Hospital of Guangzhou Medical University
Conditions	Lung Transplant Recipient
Enrollment	30 participants
Start Date	2025-08-03
Primary Completion	2025-12-30 (estimated)
Study Completion	2026-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-02-25