Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis

This randomized controlled clinical trial aimed to evaluate the effect of sonic activation using the EDDY device on root canal microbiota and postoperative pain in teeth with asymptomatic apical periodontitis. Forty patients were assigned to either a sonic activation group (EDDY) or a conventional irrigation group. Bacterial samples were collected before and after root canal treatment and analyzed using real-time PCR. Postoperative pain was assessed using a Numerical Rating Scale at various time intervals. The results showed that EDDY sonic activation significantly reduced bacterial load, while no statistically significant difference was found in postoperative pain between the groups.

NCT Number	NCT07120126
Lead Sponsor	Abdulkadir Tiftik,DDS
Conditions	Asymptomatic Apical Periodontitis, Root Canal Infection, Periapical Diseases, Dental Pain
Enrollment	40 participants
Start Date	2021-11-20
Primary Completion	2021-12-20 (estimated)
Study Completion	2022-01-10 (estimated)
Updated on ClinicalTrials.gov	2026-02-20