Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury

This study aims to evaluate the potential effects of premorbid personality on the short- and long-term global cognitive recovery in patients with severe acquired brain injury (sABI) or stroke. The secondary aims are to assess the effects of premorbid personality on the sort- and long-term recovery in autonomy (disability), cognitive functions, psycho-behavioral functioning, motor skills, and social participation. Evaluate the incidence of premorbid personality alterations. Investigate personality changes 12-18 months after the neurological event.

NCT Number	NCT07119827
Lead Sponsor	Universita di Verona Collaborators: Azienda USL Toscana Sud Est, Centro Cardinal Ferrari, Fontanellato, Parma, Fondazione IRCCS Santa Lucia, Roma, Italy, Azienda Unita Sanitaria Locale di Piacenza, Azienda Sanitaria dell'Alto Adige, Azienda Ospedaliero, Universitaria Pisana, Azienda Sanitaria Locale CN1 Cuneo, Istituto S.Anna Crotone, Montecatone Rehabilitation Institute S.p.A., Imola (Italy), IRCCS Don Carlo Gnocchi di Firenze, IRCCS Don Carlo Gnocchi Milano, CRT Montevarchi Arezzo
Conditions	Ictus, Severe Acquired Brain Injury, sABI
Enrollment	250 participants
Start Date	2025-05-01
Primary Completion	2028-05-01 (estimated)
Study Completion	2028-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-02