Clinical Trial

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

Recruiting Phase 4
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Record status
This record was last updated August 13, 2025 (before its estimated July 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley catheter has not been evaluated in prospective studies on patients with PPROM.
Trial Details
NCT Number NCT07119398
Lead Sponsor Eastern Virginia Medical School
Conditions Preterm PROM (Pregnancy)
Enrollment 80 participants
Start Date 2025-07-14
Primary Completion 2026-07-30 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-13