Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause

The purpose of this study is to evaluate the effects of single and multiple doses of ABCL635 administered by subcutaneous (SC) injection to healthy men and to postmenopausal women with or without any vasomotor symptoms (VMS) or hot flashes, and to postmenopausal women with moderate-to-severe VMS associated with menopause. The safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) parameters of ABCL635 will be assessed in all study participants; the effects on frequency and severity of VMS will be assessed in postmenopausal women who experience moderate-to-severe symptoms.

NCT Number	NCT07118891
Lead Sponsor	AbCellera Biologics Inc.
Conditions	Vasomotor Symptoms Associated With Menopause, Healthy Volunteers
Enrollment	136 participants
Start Date	2025-06-23
Primary Completion	2027-02 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2026-06-15