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Probenecid Administration for Alcohol Craving and Consumption

Study acronym: PROB2
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Nov 30, 2025 to Mar 14, 2026
    • Study sites: 0 to 1
    v3
  2. Start date: Sep 30, 2025 to Nov 30, 2025v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
Trial Details
NCT Number NCT07118618
Lead Sponsor Brown University
Conditions
(from sponsor)		 Alcohol Use Disorder (AUD), Alcohol Consumption, Craving
Related terms Alcohol Drinking, Alcoholism
Enrollment 120 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov