TMS-EEG Biomarkers for Chronic Pain

Study acronym: DELPHI TMS-EEG
StatusActive, Not Recruiting
PhaseNot applicable
Started

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Trial flagged as At Risk
Primary completion moved at least 5 months later Jun 2026 → Dec 2026
See other at-risk trials from University of California, San Francisco

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary and study completion pushed from Jun 2026 to Dec 2026
    • Eligibility criteria expanded, about 7 words
    • Secondary endpoints: details revised at 6 of 8 entries
    • Publications: details revised at 4 of 4 entries
  2. Trial status: Recruiting to Active, Not Recruiting
    • Primary and study completion dates: Jan 2026 to Jun 2026
    • Site details revised
    v3
  3. Site contact updatedv2
  4. Study First Submitted
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
In this study the investigators aim to assess the correlates of neurophysiological measures (measurement of brain magnetically evoked response) using DELPHI system. The DELPHI system device is a computerized, electromechanical medical device that produces and delivers non-invasive Transcranial Magnetic Stimulation (TMS) fields to induce electrical currents directed at regions of the cerebral cortex and records the resultant Electroencephalogram (EEG) brain electrophysiological response. DELPHI analyzes the TMS Evoked Potential (TEP) and produces quantitative output measures. Objectives include: * To use TMS-evoked EEG measures of brain function in patients with chronic pain using the QuantalX DELPHI system to predict patient specific pain diagnoses using machine learning classification methods. * To evaluate longitudinal associations between TMS-evoked EEG measures and ratings of chronic pain. * To monitor associations between TMS-evoked EEG biomarkers and therapy success for three different classes of medications.
Trial Details
NCT Number NCT07116278
Lead Sponsor University of California, San Francisco
Conditions
(from sponsor)		 Chronic Pain
Related terms Chronic Pain, Fibromyalgia, Pain
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov