Clinical Trial

Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

Recruiting
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Summary
The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs. Sham tDCS combined with Massed PE, focusing on pain and PTSD outcomes, to determine the comparative effectiveness of the two interventions on process outcomes of patient satisfaction, treatment attrition, and treatment compliance and to explore changes in blood biomarkers associated with stress and inflammatory processes related to pain and PTSD symptom improvements following treatment.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-08-04; most recent amendment 2026-03-31.
Status change: Withheld → Recruiting 2026-01-07
Trial Details
NCT Number NCT07116109
Lead Sponsor The University of Texas Health Science Center, Houston
Collaborators: United States Department of Defense
Conditions Chronic Pain, Post Traumatic Stress Disorder (PTSD)
Enrollment 146 participants
Start Date 2025-07-01
Primary Completion 2029-01-30 (estimated)
Study Completion 2029-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-03