Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation

Extracorporeal cardiopulmonary resuscitation (ECPR) constitutes a pivotal emergency intervention for cardiac arrest (CA) patients. However, current eligibility criteria and prognostic assessment metrics remain substantially limited, relying predominantly on clinical symptoms and physical signs while lacking objective biomarker data. Integrating reproducible, highly sensitive, and specific proteinaceous and metabolic indicators with ultrastructural platelet alterations may hold significant implications for both ECPR administration and prognostication in CA. Therefore, the purpose of this study is to identify the plasma proteomic and metabolomic characteristics of patients with refractory cardiac arrest before and after ECPR treatment, as well as the characteristics of platelet morphological and structural changes, to search for potential specific markers that can predict CA patients who may benefit from ECPR so as to optimize treatment selection.

NCT Number	NCT07113769
Lead Sponsor	Central China Fuwai Hospital of Zhengzhou University Collaborators: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Henan Provincial People's Hospital
Conditions	ExtraCorporeal Membrane Oxygenation (ECMO), Cardiac Arrest
Enrollment	130 participants
Start Date	2025-09-01
Primary Completion	2026-12-30 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-23