PERSONAE - a Personalized Online Treatment of Depression

The goal of this clinical trial is to determine whether a personalized online treatment for depression, delivered via an app (PERSONAE), is effective in treating mild to moderate depression in adults. The study will also assess the safety of the Monsenso app. The main questions it aims to answer are: Does the PERSONAE intervention reduce depression scores compared to standard internet-based treatment for depression? What challenges do participants experience when using the PERSONAE intervention? Researchers will compare PERSONAE to Treatment As Usual (a standard, one-size-fits-all treatment) to evaluate whether PERSONAE is more effective in treating mild to moderate depression. Participants will: Complete a 12-week online treatment program based on cognitive behavioral therapy (CBT). Undergo an intake assessment and complete weekly questionnaires. Receive guidance from a clinical psychologist tailored to their individual needs

NCT Number	NCT07113548
Lead Sponsor	Region of Southern Denmark
Conditions	Depression - Major Depressive Disorder
Enrollment	175 participants
Start Date	2025-06-10
Primary Completion	2026-10 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2025-08-15