Effects of Soluble Fiber Supplements on Sperm Quality in Males With Obesity: a Randomized Trial

Obesity-related poor sperm quality is a significant public health issue, acting as a major contributor to male infertility. Dietary intervention has emerged as an effective strategy to manage obesity and improve sperm quality. Soluble dietary fiber (SDF), an essential nutritional component, plays a crucial role in regulating host health. Notably, insufficient SDF intake has been associated with both obesity and low sperm motility. However, the effect of SDF supplementation on sperm quality in males with obesity remains unclear. Thus, we conducted a randomized, placebo-controlled study to investigate the effect of SDF supplementation on sperm quality in males with obesity.

NCT Number	NCT07112248
Lead Sponsor	Huazhong University of Science and Technology
Conditions	Obesity-related Poor Sperm Quality, Gut Microbiota
Enrollment	74 participants
Start Date	2025-08-10
Primary Completion	2026-01-04 (estimated)
Study Completion	2026-01-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-18