Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients

This clinical trial is designed to evaluate if adding the Karius Spectrum™ plasma test to usual care diagnostic tests, compared to usual care testing alone, among immunocompromised participants presenting with suspected infection in the outpatient setting leads to faster infection diagnosis and treatment. Participants will give a blood sample one time to be used for the testing. Information about the participant's illness and any treatments within 30 days following enrollment will be recorded.

NCT Number	NCT07110636
Lead Sponsor	Karius, Inc.
Conditions	Infection, Infections, Bacterial, Infections, Fungal, Infection Viral, Parasitic Disease
Enrollment	2,000 participants
Start Date	2025-10-27
Primary Completion	2028-09-15 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-30