Blended Unified Protocol for Chinese Adolescents With Non-Suicidal Self-Injury: A Randomized Controlled Trial

This study is an open-label, randomized controlled trial evaluating the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) in reducing non-suicidal self-injury (NSSI) among Chinese adolescents. This program is an annualized cognitive-behavioral therapy designed for adolescents aged 12-17 years who engage in non-suicidal self-injury behavior. Its primary goal is to reduce the intensity and frequency of distressing emotional experiences by teaching adolescents how to confront and respond to these emotions in more adaptive ways. In turn, this helps reduce self-injury impulses and behaviors. The UP-A is adapted to the Chinese cultural context and delivered as a blended treatment, combining face-to-face and online sessions.

NCT Number	NCT07110181
Lead Sponsor	Jian-Jun Ou
Conditions	Non-suicidal Self-injury (NSSI)
Enrollment	60 participants
Start Date	2025-08-15
Primary Completion	2026-03-20 (estimated)
Study Completion	2026-06-20 (estimated)
Updated on ClinicalTrials.gov	2025-08-07