hCG Priming in Women With Diminished Ovarian Reserve

The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The investigators want to retest the findings of our first study in an identical paired design (NCT04643925), as an increase of 1.5 in mean number of oocytes retrieved is clinically relevant. To incorporate the strengths of a randomized controlled trial design, women will be randomized after their first ICSI treatment to receive either hCG or placebo in a double-blinded design during an eight-week priming period preceding their second ICSI treatment. The primary outcome is the number of oocytes retrieved in the second ICSI treatment.

NCT Number	NCT07108621
Lead Sponsor	Kristine Loessl Collaborators: Copenhagen University Hospital, Hvidovre, Copenhagen University Hospital at Herlev, Odense University Hospital
Conditions	Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
Enrollment	80 participants
Start Date	2025-09
Primary Completion	2028-03-31 (estimated)
Study Completion	2031-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-17