Implementation of Red Blood Cell Transfusion Recommendations in the Pediatric Intensive Care Unit

Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric intensive care unit with increased risk of organ dysfunction, infection, delirium, and death. Recommendations have been developed to restrict transfusion in patients who are unlikely to benefit; however, these recommendations have not been consistently adopted into clinical practice. This study examines use of targeted efforts (implementation strategies) to improve implementation of the recommendations, with a goal of reducing unnecessary transfusions and improving patient outcomes in critically ill children.

NCT Number	NCT07108374
Lead Sponsor	Stanford University Collaborators: Lucile Packard Children's Hospital, Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ)
Conditions	Red Blood Cell Transfusions
Enrollment	200 participants
Start Date	2024-11-30
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-02-01 (estimated)
Updated on ClinicalTrials.gov	2025-08-07