Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

The purpose of this randomized study is to demonstrate direct clinical benefit, i.e., observed benefits in how humans with COPD feel in terms of symptoms (e.g., cough frequency, shortness of breath, and other respiratory symptoms) and function (e.g., lung function, and six-minute walking test \[6MWT\]) after switching to THS compared to continuing to smoking cigarettes.

NCT Number	NCT07108166
Lead Sponsor	Philip Morris Products S.A.
Conditions	COPD, Smoking, Tobacco Use
Enrollment	290 participants
Start Date	2025-04-02
Primary Completion	2026-08 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2026-06-15