Effect of Rehabilitation on the Respiratory Signal in Patients With COPD and Exercise-Induced Desaturation

The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia", breathing air at 1600m "hypoxia", or breathing SSOT at 760m "hyperoxia" conditions, during in-patient pulmonary rehabilitation. The objective of the main study is to provide long-awaited data concerning the use of SSOT during training. At present it is unclear whether patients with chronic lung diseases who reveal an SpO2 \> 88% at rest, but desaturate during exercise, and, thus, may not qualify for long-term oxygen undergoing PR benefit from supplemental oxygen. This sub-study will involve the subjects wearing the Respeck device and will focus on the effect of exercise on the respiratory signal measured by the Respeck.

NCT Number	NCT07107828
Lead Sponsor	Eastern Switzerland University of Applied Sciences Collaborators: University of Edinburgh, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Conditions	COPD (Chronic Obstructive Pulmonary Disease)
Enrollment	52 participants
Start Date	2025-07-23
Primary Completion	2025-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-08-06