Clinical Trial

O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock

Study acronym: OxyCarDio
Recruiting
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Summary
The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock. The main questions it aims to answer are: 1. Do common maneuvers for hemodynamic optimization (fluid bolus and/or vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator? 2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas? Participants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.
Trial Details
NCT Number NCT07107724
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions Hemodynamic Instability, Oxygen Consumption (V̇O2)
Enrollment 36 participants
Start Date 2025-07-29
Primary Completion 2027-07 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2025-08-06