Necrotizing Soft Tissue Infections

SnapNSTI is an international, multicenter, time-bound prospective observational cohort study designed to characterize current epidemiology, management patterns, and outcomes of patients with necrotizing soft-tissue infections (NSTI). The primary objective is to estimate 90-day all-cause mortality and to evaluate the variability in management across centers. The study will also explore the association between clinical characteristics, treatments, and patient-reported outcomes.

NCT Number	NCT07107555
Lead Sponsor	European Society for Trauma and Emergency Surgery Collaborators: University of Pennsylvania, Hospital del Mar Research Institute (IMIM), Hospital del Mar, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Birmingham
Conditions	Necrotizing Soft Tissue Infection, Fournier Gangrene, Sepsis, Surgical Infection, Soft Tissue Infections
Enrollment	480 participants
Start Date	2026-01-01
Primary Completion	2027-03-31 (estimated)
Study Completion	2027-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-08-06