Impact of Holotropic Breathwork on Nursing Student Mental Health

Purpose of the Study This study investigates whether Holotropic Breathwork (HB)-a technique involving controlled hyperventilation paired with music and guided support-can improve the mental, emotional, and existential well-being of nursing students. The researchers aim to: Evaluate the acceptability and impact of HB in this population. Compare psychological, interpersonal, and existential functioning before and after the breathwork session. Study Design Participants: Up to 72 current UNMC nursing students (age 19+), excluding those with bipolar/psychotic disorders, cardiac/seizure conditions, glaucoma, or recent surgeries. Pregnant individuals are excluded. Intervention: A single-day breathwork session, led by certified facilitators, including preparatory instruction, two breathwork rounds (one as "breather," one as "sitter"), and integration discussions. Data Collection: Surveys before, immediately after, and at 1-, 3-, and 6-month follow-ups. Instruments include: Patient Health Questionnaire-9 (PHQ-9) General Anxiety Disorder-7 (GAD-7) Psychological Insight Scale Self and Interpersonal Functioning Scale Purpose in Life Test Emotional Breakthrough and Mystical Experience Questionnaires Significance Nursing students face significant stress, anxiety, and even suicide risk. HB may offer a safe, non-drug intervention to support their mental health. While HB has been studied in other populations, this is the first known study targeting nursing students. Safety Measures Participants monitored by trained facilitators. Pre-screening includes a urine pregnancy test. Emergency plans include psychiatric assessment, Uber/Lyft rides if needed, and referral systems for mental health support. If \>15% of participants experience serious adverse events, the study will be halted.

NCT Number	NCT07106554
Lead Sponsor	University of Nebraska
Conditions	Mental Health
Enrollment	2 participants
Start Date	2025-08-28
Primary Completion	2025-08-31 (estimated)
Study Completion	2025-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-04