Mindfulness-based Psilocybin Therapy for PTSD

The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connectivity, and microstructural neuroplasticity assessed using EEG/EMG and multimodal MRI measures after administration of one oral dose of psilocybin, accompanied either with standard "psychological support" only; or with standard support plus Mindfulness-based Cognitive Therapy (MBCT).

NCT Number	NCT07104916
Lead Sponsor	Anthony P King Collaborators: Ohio State University
Conditions	Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Enrollment	30 participants
Start Date	2026-07-01
Primary Completion	2029-09 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-06-25