MHT and Liver Function in Postmenopausal Women

This prospective study aims to evaluate the effects of menopausal hormone therapy (MHT) on liver function, lipid profiles, and hepatic steatosis in postmenopausal women. A total of 44 participants will be divided into two groups: 22 received MHT and 22 were monitored without treatment. Biochemical parameters, FIB-4 scores, and attenuation imaging (ATI) measurements are assessed at baseline and after six months. The study investigates whether MHT is associated with favorable changes in liver enzymes, hepatic fat accumulation, and noninvasive fibrosis markers.

NCT Number	NCT07103603
Lead Sponsor	Ipek B. Ozcivit Erkan, MD
Conditions	Menopause, Non Alcholic Fatty Liver Disease, Hepatic Steatosis
Enrollment	44 participants
Start Date	2024-10-30
Primary Completion	2025-09-30 (estimated)
Study Completion	2025-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-27