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Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Study acronym: PACESS
StatusActive, Not Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Enrollment closed, study ongoing
    • Primary completion date changed from estimate of Aug 2027 to Jul 23, 2026
    • Site details revised
    v4
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Aug 2025 to Aug 26, 2025
    • Site details revised
    v3
  3. Interventions: Acetaminophen + Ketorolac/Ibuprofen Simultaneous (Drug), Acetaminophen + Ketorolac/Ibuprofen Staggered (Drug) to Acetaminophen (Drug), NSAID (Ketorolac/Ibuprofen) (Drug)v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.
Trial Details
NCT Number NCT07102641
Lead Sponsor Thomas Jefferson University
Conditions
(from sponsor)		 Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain, NSAIDs, Acetaminophen (D000082)
Related terms Postoperative Pain
Enrollment 825 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov