A Prediction Model in Pregnant Women With Aplastic Anemia

Aplastic anemia (AA) is a rare haematologic disorder characterized by bone marrow failure and pancytopenia. Its occurrence during pregnancy is exceedingly rare but poses significant risks, including maternal hemorrhage, infections, and perinatal complications such as preterm birth and fetal growth restriction. Consequently, pregnancy with AA is highly perilous for both mothers and infants. Early management is critical to ensure the health of both the mother and the baby. However, there are currently no predictive tools available to assess adverse outcomes in pregnant women with AA. Our center plans to conduct a multicenter, combined retrospective and prospective cohort study.

NCT Number	NCT07101770
Lead Sponsor	Peking University People's Hospital Collaborators: Tianjin Medical University General Hospital, Lanzhou University Second Hospital, The Affiliated Hospital of Inner Mongolia Medical University, General Hospital of Ningxia Medical University, Peking Union Medical College Hospital, Peking University Third Hospital, The First Affiliated Hospital of Anhui Medical University, Wuhan TongJi Hospital, Peking University First Hospital, Chinese PLA General Hospital, Second Xiangya Hospital of Central South University, The First Affiliated Hospital of Soochow University, Qilu Hospital of Shandong University, Shanxi Provincial People's Hospital, The First Affiliated Hospital of Zhengzhou University, Shandong Provincial Hospital, Shanxi Bethune Hospital, Yantai Yuhuangding Hospital, First Affiliated Hospital of Harbin Medical University, The Third Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of Zhejiang University, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions	Aplastic Anemia, Pregnancy, Prediction Model
Enrollment	300 participants
Start Date	2025-11-27
Primary Completion	2030-06-30 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-01