A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits

This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.

NCT Number	NCT07101003
Lead Sponsor	Marwa Hisham Mohamed Salah Eldin
Conditions	Apical Periodontitis, Necrotic Pulps, Single Rooted Teeth
Enrollment	28 participants
Start Date	2025-08-01
Primary Completion	2025-08-01 (estimated)
Study Completion	2025-08-04 (estimated)
Updated on ClinicalTrials.gov	2025-08-03