Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain

Inclusion Criteria: Premenopausal woman between age 2118 and 49 years (inclusive) at the time of consent. Menopause [...] ery (visual or biopsy confirmed), ultrasound, or MRI within 510 years of study entry History of self-reported moderate to s [...] c pain for ≥ 6 months' duration at time of screening visit. Moderate-to-severe pelvic pain will be defined as self-report recall of average non-menstrual pelvic pain score over past 6 months as ≥ 4 on a 0-10 numeric rating scale (NRS) Willingness to participate in a relugolix CT drug intervention trial No use of adjunctive pain medications or on stable chroni [...] [...]

[...] n Arbor, MI and Henry Ford, Detroit, MI and via social media and regional patient support groups). Endometrial biopsies will be sent via overnight courier t [...]