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Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus

StatusCompleted
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Completed without a posted recruiting period Final enrollment: 36 participants (planned 30) · Primary completion date changed from estimate of Sep 1, 2027 to Aug 16, 2026 · Study sites: 0 to 1 · 3 more Show 6 more changesShow less
    • Final enrollment: 36 participants (planned 30)
    • Primary completion date changed from estimate of Sep 1, 2027 to Aug 16, 2026
    • Study sites: 0 to 1
    • Study completion date changed from estimate of Dec 1, 2027 to Sep 26, 2026
    • Start date changed from estimate of Jan 1, 2026 to Nov 11, 2025
    • Eligibility criteria expanded, about 10 words
  2. Eligibility criteria shortened, about 9 wordsv2 See this version in full on ClinicalTrials.gov ↗
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
In oral lichen planus ,Tumor necrosis factor-alpha (TNF-α) has a role in the progression of the disease, enhancing CD8+ cytotoxic T cells and plays a role in the malignant transformation of the lesion. IL-10 is an anti-inflammatory cytokine that controls the disease and maintain homeoastasis. Treatment for OLP includes corticosteroids which is the gold standard, although they have considerable side effects. The use of herbal medicine as an alternative therapy seems promising. Coconut oil has anti-inflammatory, antioxidant, and immunomodulatory properties, no adverse effects, easily available, cost-effective and simply extracted.The aim of this randomized controlled clinical trial is to compare the therapeutic effects of topical 50% coconut mucobioadhesive gel versus topical corticosteroid gel in the management of symptomatic OLP clinically and using biochemical analysis
Trial Details
NCT Number NCT07100145
Lead Sponsor Ain Shams University
Conditions Oral Lichen Planus
Enrollment 36 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov