"Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds"

This study aims to evaluate whether using ultrasound (phonophoresis) can help deliver propolis-a natural compound made by bees-more effectively into the skin to speed up wound healing in people with diabetic foot ulcers. Diabetic foot ulcers are a common and serious complication of diabetes and often take a long time to heal. Propolis has natural anti-inflammatory and antimicrobial properties that may promote healing, but it does not easily penetrate the skin. By using ultrasound to enhance absorption, this study tests whether combining propolis with phonophoresis is more effective than standard wound care alone. Participants will be randomly assigned to receive either the propolis ultrasound therapy or standard care. The study will measure wound size, healing time, pain, infection rates, and quality of life.

NCT Number	NCT07099482
Lead Sponsor	Sinai University
Conditions	Diabetic Foot Ulcer t, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Wound Management, Chronic Wound Healing
Enrollment	80 participants
Start Date	2026-08-30
Primary Completion	2027-08-25 (estimated)
Study Completion	2027-09-25 (estimated)
Updated on ClinicalTrials.gov	2026-08-04