A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.

NCT Number	NCT07098611
Lead Sponsor	Medipol University Collaborators: International Association of Non Invasive Ventilation, International Academy of Non Invasive Ventilation, International College of Experts of Non Invasive Ventilation
Conditions	Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness, Extubation Failure, Extubation Succeeded, Intensive Care Patients Invasively Ventilated, Weaning Invasive Mechanical Ventilation
Enrollment	470 participants
Start Date	2025-06-15
Primary Completion	2026-12-30 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-05