Intranasal LAIV Mucosal Immunity Examination

The research of the investigators is focused on the understanding how the immune system functions and responds to intranasal vaccines. Intranasal vaccines do not lead to the same changes in the blood that intramuscular vaccines do. Therefore, the investigators want to look at the function of immune (lymphoid) organs that are near the nose. The closest immune organs are the adenoids and tonsils. Mice do not have tonsils allowing for the investigators to answer these questions. Human lymphoid tissue will allow the investigators to better understand the molecular behavior of these cells in humans. The purpose of this protocol is to administer the FDA approved live attenuated influenza vaccine or no vaccine to patients undergoing adenoidectomy and/or tonsillectomy for obstructive sleep apnea prior to surgery and then collect the tissue (adenoid and/or tonsil tissue) that would normally be discarded from surgery. This will allow for improved understanding of what happens after vaccination.

NCT Number	NCT07093281
Lead Sponsor	University of Maryland, Baltimore
Conditions	Impact of Vaccination
Enrollment	25 participants
Start Date	2026-02
Primary Completion	2026-04 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2025-12-19