Comparison of Post-Craniotomy Blood Pressure Targets

The goal of this pragmatic clinical trial is to learn if a more intensive or more liberal blood pressure target after surgery is more effective in improving patient outcomes for adults undergoing craniotomy for removal of a brain tumor. There is little evidence to help doctors decide the best post-operative blood pressure target for their patients. The main question this study aims to answer is if patients with a post-operative systolic blood pressure target of \<160 mmHg will have a shorter hospital length of stay than those with a blood pressure target of \<140 mmHg, without increasing the rate of post-operative bleeding in the brain.

NCT Number	NCT07093151
Lead Sponsor	Vanderbilt University Medical Center
Conditions	Intracranial Hemorrhage, Hypertensive, Craniotomy Tumor Removal Surgery
Enrollment	500 participants
Start Date	2026-04-15
Primary Completion	2028-06 (estimated)
Study Completion	2028-09 (estimated)
Updated on ClinicalTrials.gov	2026-04-21