Clinical Trial

Tenecteplase for Intravenous Stroke Thrombolysis in Recent DOAC Users

Study acronym: PEARL-DOAC
Recruiting Phase 3
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Summary
An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind trial to determine the efficacy and safety of intravenous tenecteplase thrombolysis in acute ischemic stroke (AIS) patients with recent direct oral anticoagulants (DOACs) intake in improving the 90-day functional outcome.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-07-22.
Status change: Not Yet Recruiting → Recruiting 2025-12-08
Trial Details
NCT Number NCT07092709
Lead Sponsor Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions Acute Ischemic Stroke
Enrollment 912 participants
Start Date 2025-08-14
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-16