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Tenecteplase for Intravenous Stroke Thrombolysis in Recent DOAC Users

Study acronym: PEARL-DOAC
StatusRecruiting
PhasePhase 3
Started2025-08-14
View on ClinicalTrials.gov ↗

Amendment history

2025-12-08
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-08-01→confirmed 2025-08-14
Study sitesdetails revised at 1 of 1 site
2025-07-22
Original filing
An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind trial to determine the efficacy and safety of intravenous tenecteplase thrombolysis in acute ischemic stroke (AIS) patients with recent direct oral anticoagulants (DOACs) intake in improving the 90-day functional outcome.
Trial Details
NCT Number NCT07092709
Lead Sponsor Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions Acute Ischemic Stroke
Enrollment 912 participants
Start Date 2025-08-14
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-16