Mediation Analysis in Cardiac Surgery

This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.

NCT Number	NCT07092683
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Anemia, Cardiac Surgery, Transfusion, Mediation
Enrollment	13,683 participants
Start Date	2025-01-01
Primary Completion	2025-05-01 (estimated)
Study Completion	2025-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-05